Product Description

5-Aminolevulinic Acid Methyl Ester HCl (Methyl Aminolevulinate Hydrochloride, m-ALA HCl) is a lipophilic methyl ester derivative of 5-aminolevulinic acid. This esterified form is designed to enhance skin penetration compared to the parent hydrophilic molecule, making it suitable for topical cosmetic applications. As a prodrug, it is metabolized to Protoporphyrin IX (PpIX), a photoactive compound that interacts with specific light wavelengths.

Our Cosmetic Grade m-ALA HCl is produced via microbial fermentation and ion exchange purification, meeting ≥98% purity (HPLC). It appears as a white to off-white crystalline powder.

Quick Details

Key Characteristics

Enhanced Lipophilicity — The methyl ester modification increases the molecule‘s lipophilic character compared to 5-ALA, facilitating improved penetration through the stratum corneum barrier. It shows much higher lipophilicity and is highly efficient at inducing protoporphyrin IX production in cell culture.

Fermentation-Derived — Produced through microbial fermentation, ensuring consistent quality and high purity.

Water-Soluble Active — Despite enhanced lipophilicity, m-ALA HCl retains good water solubility for ease of incorporation into aqueous formulations.

Light-Sensitive — Requires protection from light during storage and formulation; finished products should use opaque packaging.

The Main Application for 5-Aminolevulinic Acid Methyl Ester HCl Powder?

1) Professional Skin Care Protocols
m-ALA HCl is incorporated into professional formulations used in conjunction with specific light-based protocols for skin appearance improvement. Clinical research has evaluated compositions containing 0.5% by weight of 5-ALA derivatives, applied for 1 hour followed by red light illumination at 635 nm.

2) Anti-Aging & Skin Texture Formulations
Patented cosmetic compositions describe the use of ALA esters in formulations targeting signs of skin ageing, including fine lines, wrinkles, reduced elasticity, and uneven skin tone.

3) Rinse-off and Leave-on Products
m-ALA HCl is suitable for various cosmetic formats including creams, serums, and gel-based formulations. Korean patent literature describes skin external cosmetic compositions for acne and skin improvement containing methyl 5-aminolevulinate hydrochloride in cream, ointment, or lotion forms.

Why Choose Our m-ALA HCl?

 Fermentation-derived — consistent quality via microbial production

 ≥98% HPLC purity — verified potency for demanding formulations 

 Enhanced lipophilicity — improved penetration profile vs. 5-ALA 

 Water-soluble — easy incorporation into aqueous systems

 Full documentation — COA, MSDS, TDS available upon request

Request some sample or want to order the 5-Aminolevulinic Acid Methyl Ester HCl Powder, Contact DIELEGANCE BIOTECH technical sales team to ask more details for supporting your formulations.